PENGARUH PEMBERIAN NATRIUM DIKLOFENAK DOSIS 1,4 MG/KgBB DAN 2,8 MG/KgBB TERHADAP KADAR UREUM TIKUS WISTAR

Abstract

Background Diclofenac sodium is an NSAID that is often used to treat musculoskeletal pain, such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, spondiloartritis, and gouty arthritis. The side effects were reported in 30% of patients in the form of impaired renal function. This drug is known to cause oliguria caused by a decrease in renal blood flow and glomerular filtration rate of the kidneys. Aim To know the effect of diclofenac sodium 1,4 mg/kgBW and 2,8 mg/kgBW oral administration toward serum levels of urea of wistar rats. Methods Experimental study Post Test Only Control Group Design. The samples were 21 male wistar rats, randomized in to 3 groups. Group I was not given diclofenac sodium (control), Group II was given diclofenac sodium 0,6 mg and Group III was given diclofenac sodium 1,2 mg. Administration through gastric instillation thrice a day for 14 days. Blood samples were collected at the 15th day through retroorbital vascular and the urea levels were measured using standard methods. Data analysis used One-Way ANOVA Test and Post-Hock Test. Statistical analysis was conducted by computer program. Results There was no significant increase in the average value of the urea levels from the control group toward Group II and Group III. One-Way ANOVA test showed that there was no significant difference (p=0.819) among all of groups. Post-Hock test also showed that there were no significant differences in the control group toward Group II (p=0.554), control group toward Group III (p=0.649), and Group II toward Group III (p=0,889). Conclusion Administration of diclofenac sodium 1.4 mg/kgBW and 2.8 mg/kgBW for 14 days did not cause a significant increase in urea levels. Key Words: Diclofenac sodium, urea levels.