HUBUNGAN ANTARA KOINFEKSI TUBERKULOSIS DENGAN KEJADIAN TREMOR PADA PASIEN HIV/AIDS Studi Kasus di RSUP Dr. Kariadi dan Balai Kesehatan Paru Masyarakat wilayah Semarang

Abstract

Background: Neurons are host cell for Mycobacterium Tuberculosis. M.tuberculosis bacilli live and replicate in neuritis and the soma. CD4 got an important role on its replication. The lower CD4 counts, the highest replication numbers will be. This phenomenon will cause a neurological manifestation as a direct consequence of tuberculosis infection. One of the neurological manifestations is a movement disorder such as tremor. Aim: Determine the association between Tuberculosis co-infection with tremor prevalence among HIV/AIDS patients. Methods: This study was an observational analytic study using cross sectional methods. Twenty four patients were divided into TB-HIV group (15 samples) and control group (9 samples). All respondents had their tremor manifestation observed and examined. Secondary data were collected from patient’s medical records. Obtained data were analyzed using Fischer Exact Test. Results: The prevalence of tremor was 13,3% in TB-HIV group. There was no significant association between tuberculosis infection with tremor incidence (p=0,511). Sex, HAART, anti tuberculosis drugs, and age also has no association with tremor in TB-HIV group. Conclusion: There is no significant association between tuberculosis co-infection with tremor prevalence among HIV/AIDS patients in Dr. Kariadi Hospital and Lung Health Community Centre district Semarang. Keywords: tremor, TB-HIV, HIV/AIDS