PERBEDAAN PROFIL KLINIS PENYAKIT DEMAM BERDARAH DENGUE (DBD) PADA ANAK DAN DEWASA

Abstract

Background : Dengue hemorrhagic fever is a communicable disease commonly found in tropical and subtropical area and a major health problem in Indonesia. This disease can lead to different clinical profiles between children and adults. Aim : To analyze the differences of clinical profile consist of duration of fever, hemorrhagic manifestations, hepatomegaly, plasma leakage, and the degree of dengue hemorrhagic fever (DHF) in children and adults. Methods : This research was an observational study with cross sectional retrospective design. Total of samples were 154 consisting of 79 children and 75 adults who are diagnosed dengue hemorrhagic fever. Data was obtained from medical records from January 2013 to March 2015. Statistical test was using Chi square test, Mann Whitney, and two samples Kolmogorov Smirnov with significance limit of p < 0.05 and a confidence interval of 95% . Result : Chi square test found no significant difference in duration of fever (p = 0,304), and found significant differences in spontaneous bleeding (p = 0.001), hepatomegaly (p < 0.001), shock ( p < 0.001) and plasma leakage ( p < 0.001) which is more common in children than in adults . Mann Whitney test found significant differences in the mean time of fever duration (p = 0.017) which longer in adults (6.61 days). Two samples Kolmogorov -Smirnov test found significant differences in the degree of DHF ( p = 0.004 ) . Conclusion : There were significant differences (p>0,05) of clinical profile consist of mean time of fever duration, spontaneous bleeding manifestations (especially petechiae and ecchymosis/ purpura), hepatomegaly, shock, plasma leakage (especially hemoconcentration, pleural effusion, and edema palpebra), and the degree of DHF. Keywords : DHF, clinical profile, fever duration, bleeding, hepatomegaly, shock, plasma leakage, grade, children, adults