FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN ANEMIA PADA PEMAKAIAN ZIDOVUDIN PASIEN HIV/AIDS

Abstract

Background: The administration of Zidovudine (ZDV) has an important role in decreasing the number of mortality on HIV/AIDS patients. Nevertheless, Zidovudine is known to make a side effect of anaemia. The incidence of anaemia can be influenced by several factors, e.g. age, sex, duration of therapy, CD4 count, and ALT count. Aims: This research aims to determine factors influencing incidence of anaemia on HIV/AIDS patients with Zidovudine treatment in Dr. Kariadi General Hospital Semarang and see the correlation between those determinant factors to the incidence of anaemia. Methods: This research is an analytic observational with cohort-retrospective method used. There were 70 HIV/AIDS patients with Zidovudine, divided into two groups: 35 patients belonged to case group, while the other 35 patients belonged to control group. The data was taken from medical records and analyzed by Chisquare and Fischer test. Results: Age did not have any correlation to incidence of anaemia (p=0.075). Sex was a contributing factor to incidence of anaemia (p=0.027) in which female patients were more susceptible to anaemia. Duration of therapy was a contributing factor to incidence of anaemia (p=0.000) particularly patients with less than 12 months of therapy. CD4 count did not have any correlation to incidence of anaemia (p=0.055). ALT count did not have any correlation to incidence of anaemia (p=1.000). Conclusion: The administration of Zidovudine corresponds to the incidence of anaemia with sex and duration of therapy as the influencing factors on HIV/AIDS patients in Dr. Kariadi General Hospital Semarang. Keywords: HIV/AIDS, Zidovudine, Anaemia