PERBANDINGAN PROFIL HEMATOLOGI PADA PREEKLAMPSIA/ EKLAMPSIA DENGAN KEHAMILAN NORMOTENSI DI RSUP DR. KARIADI SEMARANG

Abstract

Background: Preeclampsia is hypertension accompanied by proteinuria and edema which was one of the major cause of maternal death in Indonesia. There are changes hematological profile in preeclampsia. Aim: To compare the hematological profile of preeclampsia and eclampsia with normotensive pregnancies at RSUP Dr. Kariadi Semarang. Methods: This was a cross-sectional with observational analysis. Data was taken from the medical records of pregnant and labor women in Hospital Dr. Kariadi 2014. The assessment of hematogical profile consisted of the number of erythrocytes, hemoglobin concentration, hematocrit levels, levels of MCV, MCH, MCHC, leukocyte count, and platelet count. The data were statistically analized using the comparative test of One Way ANOVA and Kruskal-Wallis as alternative test. Results: There were 13 patients with mild preeclampsia, 56 patients with severe preeclampsia, eclampsia 16 patients and 85 patients with normotensive. Hematocrit increased significantly in severe preeclampsia compared with mild preeclampsia and controls (p < 0.000). Leukocyte levels were significantly higher in severe preeclampsia compared with controls (p < 0.000). Hematocrit and leukocytes in mild preeclampsia and eclampsia showed no significant difference compared with normotensive pregnancies. There was a significant difference in the number of erythrocytes (p < 0.000) and hemoglobin (p < 0.001). There is no significant difference in MCH level (p < 0.870), MCV level (p < 0.770), MCHC level (p < 0.300), and platelets count (p < 0.425). Conclusion: Hematocrit in patients with severe preeclampsia was higher than mild preeclampsia and normotensive pregnancies. There was an increase in the number of leukocytes in patients with severe preeclampsia compared with normotensive pregnancies. There is no difference in hematocrit and leukocytes in mild preeclampsia and eclampsia than normotensive pregnancy. There were differences in the number of erythrocytes and hemoglobin. There was no differences in the levels of MCH, MCV, MCHC and platelets. Keywords: preeclampsia, eclampsia, hematological profile