What role do coagulation disorders play in the pathogenesis of leptospirosis?

Wagenaar, Jiri F.P. and Goris, Marga G.A. and Sakundarno, Mateus and Gasem, M. Hussein and Mairuhu, ATA and de Kruif, MD and ten Cate, H and Hartskeerl, Rudy A. and Brandjes, DPM and van Gorp, Eric C. M. (2007) What role do coagulation disorders play in the pathogenesis of leptospirosis? Tropical Medicine and International Health, 12 (1). pp. 111-122.

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Leptospirosis is a zoonosis of worldwide distribution, spread by the urine of infected animals. It is a major public health problem, especially in developing countries, where circumstances for transmission are most favourable. The clinical picture varies from mild disease to a severe illness with haemostatic derangements and multiorgan failure eventually leading to death. Although the haemorrhagic complications of severe disease are serious, the pathophysiology is scarcely elucidated. The complex mechanisms involved in inflammation-induced coagulation activation are extensively studied in various infectious diseases, i.e. Gram-negative sepsis. Tissue factor-mediated coagulation activation, impairment of anticoagulant and fibrinolytic pathways in close concert with the cytokine network are thought to be important. But for human leptospirosis, data are limited. Because of the growing interest in this field, the impact of leptospirosis, and the availability of new therapeutic strategies, we reviewed the evidence regarding the role of coagulation in leptospirosis and provide suggestions for future research.

Item Type:Article
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:Faculty of Public Health > Department of Public Health
ID Code:447
Deposited By:Mr. Sugeng Priyanto
Deposited On:01 Sep 2009 13:01
Last Modified:01 Sep 2009 13:01

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