Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever

Dharmana, Edy and Djokomoeljanto, Robert and Keuter, Monique and Gasem, M. Hussein and van der Ven-Jongekrijg, Johanna and Dolmans, Wil M. V. and Demacker, Pierre and Sauerwein, Robert and Gallati , Robert Sauerwein and van der Meer, Jos W. M. (1994) Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever. The Journal of Infection Diseases, 169 . pp. 1306-1311. ISSN 0022-1899

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Cytokines and inhibitors in plasma were measured in 44 patients with typhoid fever. Ex vivo production of the cytokines was analyzed in a whole blood culture system with and without lipopolysaccharide (LPS). Acute phase circulating concentrations of cytokines (±SD) were as follows: interleukin (IL)-1β <140 pg/mL; tumor necrosis factor-α (TNFα), 130 ± 50 pg/mL; IL-6, 96 ± 131 pg/mL; and IL-8, 278 ± 293 pg/mL. Circulating inhibitors were elevated in the acute phase: IL-1 receptor antagonist (IL-1RA) was 2304 ± 1427 pg/mL and soluble TNF receptors 55 and 75 were 4973 ± 2644 pg/mL and 22,865 ± 15,143 pg/mL, respectively. LPS-stimulated production of cytokines was lower during the acute phase than during convalescence (mean values: IL-1β, 2547 vs. 6576 pg/mL; TNFα, 2609 vs. 6338 pg/mL; IL-6, 2416 vs. 7713 pg/mL). LPS-stimulated production of IL-1 RA was higher in the acute than during the convalescent phase (5608 vs. 3977 pg/mL). Inhibited production of cytokines during the acute phase may be due to a switch from a proinflammatory to an antiinflammatory mode.

Item Type:Article
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:384
Deposited By:Mr. Sugeng Priyanto
Deposited On:13 Aug 2009 15:43
Last Modified:13 Aug 2009 15:43

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