PROFIL IMUNOPOSITIVITAS PROTEIN EBV PADA PENDERITA KARSINOMA NASOFARING DAN INDIVIDU SEHAT BERISIKO

NURYADIN, IRWAN and Prasetyo, Awal (2012) PROFIL IMUNOPOSITIVITAS PROTEIN EBV PADA PENDERITA KARSINOMA NASOFARING DAN INDIVIDU SEHAT BERISIKO. Undergraduate thesis, Fakultas Kedokteran.

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Abstract

Background: Epstein-Barr virus (EBV)-specific immunoblot analysis was used to reveal antibody responses against Epstein-Barr virus-encoded proteins in serum samples from patients with nasopharyngeal carcinoma (NPC) and control subject. Aim: To investigate the difference of Epstein-Barr virus-encoded proteins immunopositivity in the serum sampels from patients with nasopharyngeal carcinoma (NPC) and control subject. Methods: Observational analytic case-control. The sample was a group of 20 patients with nasopharyngeal carcinoma and the control group consisted of 20 persons who had no history of the cancer. Epstein-Barr virus-encoded proteins immunopositivity was determined by immunoblot analysis. Result: The Mann-Whitney test for Epstein-Barr virus-encoded proteins immunopositivity count between patients with nasopharyngeal carcinoma vs control group : VCA-p18 (p=0.041), VCA-p40 (p=0.035) and EA-p47/54 (p=0.009) were significant, but ZEBRA(p=0.140) , EBNA1 (p=0.540), TK(p=0.713), and DNAse (p=0.740) were not significantly different. Conclusion: Statistical analysis showed significant difference in VCA-p18, VCAp40 and EA-p47/54 between the two groups. Keywords: Epstein-Barr virus-encoded proteins, nasopharyngeal carcinoma, immunoblot

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:37559
Deposited By:Ms Lutfiatun Heni
Deposited On:07 Dec 2012 09:17
Last Modified:07 Dec 2012 09:17

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