ANALISIS FUNGSI FAGOSITOSIS SEL LEUKOSIT PENDERITA SINUSITIS KRONIK PADA PENGOBATAN GURAH

Abstract

Background: Gurah is a traditional medicine from Indonesia, using plants and herbs from Indonesia. The purpose of gurah is to clean respiratory system. Nowadays, gurah is used to chronic sinusitis therapy. Research on the relationship between mucociliary transport of chronic sinusitis and gurah has been done, but no previous studies has been examine the correlating between phagocytosis activity in chronic sinusitis and gurah. Aim: To analyze the changes of leukocyte phagocytosis function of patient with chronic sinusitis using standardized gurah treatment with root of Senggugu (Clerodendron serratum Spreng). Method: The study used an observational study with pre and post controlled group design of 66 patients with chronic sinusitis in Technical Services Unit SP3T Central Java and Dr Kariadi Hospital. Patients who had gurah were a treatment group and patients who had not gurah were a control group. All samples were taken their clinical data and examined their phagocytosis activity. Results: The average of phagocytosis activity for patient before gurah was 100,17±19,0%. The average of phagocytosis activity for patient at 1 week after gurah was 98,43 ± 17,7%. There was no significant differences (p=0,743) between the phagocytosis activity before gurah and 1 week after gurah. There was significant differences (p=0,006) between treatment group and control group at one week after gurah. Phagocytosis activity was constant in treatment group with no significant decline (p=0,743), whereas in the control group, there was a significant decline (p=0,001). Conclusion: Phagocytosis activity of chronic sinusitis patients in gurah treatment group better than control group at one week after gurah. Key words: gurah, phagocytosis activity, chemiluminescene method.