PENGARUH PEMBERIAN HEPARIN INTRAVENA SEBAGAI PROFILAKSIS DVT TERHADAP KADAR D-DIMER PLASMA

Abstract

Background. Thrombosis is the most causal of death, one of the thrombosis abnormalities is deep venous thrombosis (Deep Vein Thrombosis / DVT). Deep venous thrombosis (DVT) is a condition that must be quickly diagnosed and treated. DVT can lead to complications if not treated properly, complications can occur in the form of pulmonary embolism, phlebitis syndrome, chronic pulmonary thromboembolic hypertension and death. One of the prevention which can be done is by giving heparin intravenously. The administration of heparin intravenously can reduce the number of DVT by reviewing the decreased levels of D-dimer. Aim. This study is aimed to proof the effect of giving heparin intravenously to reduce levels of D-dimer. Methods. The study design was experimental with the study design pre and posttest one group design. Sample consisted of 10 patients treated in the ICU department of dr. Kariadi Semarang General Hospital who have met the inclusion and exclusion criteria. Patients were given heparin intravenously using a syringe pump, 1 hour before and after administration of heparin intravenously perform examination of D-dimer levels. Hypothesis test used Pair T-test to compare D-dimer levels before and after administration of heparin intravenously. Results. There is difference in the D-dimer levels before and after administration of heparin intravenously. The statistical results with of the Pair T-test showed no significant differences in the levels of D-dimer before and after administration of heparin intravenously, namely p = 0.403 (p > 0.05). Conclusion. There is no significant reduction of D-dimer levels after administration of heparin intravenously on patients in the ICU department of dr. Kariadi Semarang General Hospital who are at risk of DVT. Keywords: D-dimer, heparin intravenously