PERBEDAAN PENGARUH PEMBERIAN PROPOFOL DAN ETOMIDATE TERHADAP KADAR PROCALCITONIN PADA OPERASI MASTEKTOMI

Abstract

Background: Patients who major surgery with general anesthesia are greatly in risk of post-operative sepsis and Systemic Inflamatory Response Syndrome (SIRS). One of the marker that can be used to check it is procalcitonin. Anesthetic induction medicines that is oftenly used are propofol and etomidate. Objectives: To know the different between propofol and etomidate use as induction medicines towards procalcitonin level changes in surgery with general anesthesia. Methods: This study is an observational study with cross sectional design. Source of the data is from secondary data with 16 people as samples. Patients who are eligible for the inclusion and exclusion criteria are divided into two groups. In group 1, patients got propofol induction 2,5 mg/kg body weight, and group 2 got etomidate induction 0,3 mg/kg body weight. Procalcitonin is being recorded in times before experiment, 4 hours after experiment, and 24 hours after experiment. Results: In this study, shows levels of PCT in the propofol group was before induced at 0.050  0.000 ng/ml, 4 hours after induction of 0.061  0.125 ng/ml and 24 hours after induction of 0.175  0.456 ng/ml. Propofol increased significantly in group 1 with p = 0.008 (<0.05). While the group just before-induced etomidat 0.050  0.000 ng/ml, 4 hours after induced 0.050  0.000 ng/ml and 24 hours after induced 0.050  0.000 ng/ml. There was no significant increases with p = 1.00 (p> 0.05). The comparison between group 1 and 2 is significantly seen in 24 hours after experiment with p=0,038 (p<0,05). Conclusion: Propofol significantly increases procalcitonin level compared to etomidate.. Keywords: propofol, etomidate, procalcitonin, general anesthesia.