UJI BANDING EFEKTIVITAS EKSTRAK DAUN SIRIH MERAH (PIPER CROCATUM) DENGAN ZINC PYRITHIONE 1% TERHADAP PERTUMBUHAN PITYROSPORUM OVALE PADA PENDERITA BERKETOMBE

Abstract

Background Red betel vine leaves were natural materials. Zinc pythitione is very effective to inhibit the growth of P. ovale, because the work interfere with membran transport by inhibiting the proton pump mechanism of energy so as to inhibit fungal growth. Dandruff is the excessive scales production of the scalp with or without the signs of inflammations.P. ovale is assumed to play an important role in evoking dandruff. Aim To prove the effectiveness of 100% red betel vine leaves extract (Piper crocatum) with 1% zinc pyrithione in inhibiting the growth of P. ovale in dandruff sufferers in vitro. Methods This study was done by laboratory experimental method with Post test only control group desaign. As sample were 30 patiens of dandruff with clinical founding. Diagnosis of p. ovale was based on the result of microscopic examination of skin scrapping from samples using KOH 10% with blue black parker ink, and inoculation on the olive oil Sabouraund Dextrose Agar plus chloramfenicol media on 370 C for 2-5 days. The data were analyzed by Chi-Square or Fisher Exact Test p value ≤ 0,05 was considered significant. Results 30 media of olive oil SDA which contained 100% red betel vine leaves extract,28 were found P. ovale negative (-) and 2 were found P. ovale positive (+). And 30 media which contained 1% zinc pyrithione, 1 were found P. ovale positive (+) and 29 were found P. ovale negative (-) . Conclusion 100% red betel vine leaves extract (Piper crocatum) were comparable to 1% zinc pyrithione in inhibited the growth of P. ovale. Key Words Dandruff, P. ovale, 100% red betel vine leave extract, 1% zinc pyrithione.