Perbandingan Minyak Biji Singkong (Manihot esculenta) dengan Ketokonazol 2 % dalam Menghambat Pertumbuhan Candida sp pada Kandidiasis Interdigital

Abstract

Background : Candidiasis is an infection of interdigital finger sidelines caused by Candida sp. Seed oil cassava (Manihot esculenta) has been reported to inhibit the growth of Candida sp. Ketoconazole is an imidazole compound which is a standard drug in candidiasis. This study aims to compare the seed oil of cassava (Manihot esculenta) with 2% ketoconazole in inhibiting the growth of Candida sp in interdigital candidiasis. Methods : This study was an experimental research laboratory with the design of post test only control group design. The sample consisted of 30 cultures of Candida sp (+) On medium Sabouraud Dextrose Agar (SDA). Each planted on 4 media, SDAcontaining ketoconazole 2%, SDA-containing cassava (Manihot esculenta) seed oil 25%, SDA that contains only Candida sp as control (+) and SDA with formalin as a control (-) were incubated at 37 ° C for 24-48 hours. Data obtained by looking at the growth of colonies of Candida sp In both types of media. Result : Of the 30 media SDA + cassava (Manihot esculenta) seed oils, 8 medium were (+) Candida sp and 22 medium were (-) Candida sp. While 30 media SDA + ketoconazole 2%, 5 medium were (+) Candida sp and 25 medium were (-) Candida sp. From the chi-square test results obtained p = 0.347 (not significant) Conclusion : cassava (Manihot esculenta) seed oil 25% can inhibit the growth of Candida sp and comparable with ketoconazole 2% in inhibiting Candida sp in interdigital candidiasis in vitro. Key words: Candida interdigital, cassava seed oil, Candida sp.