PERBEDAAN PENGARUH PEMBERIAN PROPOFOL PENTOTHAL DAN ETOMIDAT TERHADAP KADAR LEUKOSIT PADA OPERASI MASTEKTOMI

Abstract

Background: Leukocyte is a marker of the inflammatory response to infection. Induction anesthetic agent usage is known for the leukocyte increases. Aim: This study aimed to prove the difference between propofol, pentothal and etomidat administration in increasing the leukocyte concentration in general anesthesia. Methods: An observational study with cross sectional approach. Data were derived from secondary data with total sample of 24 patients who had mastectomy operation and divided into three groups. Group 1 was given propofol 2,5 mg/kg, group 2 was given pentothal 5 mg/kg and group 3 was given etomidate 0,3 mg/kg. The blood specimen was taken from each group before anesthetic induction, four hours post induction and twenty four hours post induction. All specimens were taken to the Clinical Pathology Laboratory for leukocyte concentration testing. Results: The results showed a significant difference in percentage of procalcitonin concentration before and after the administration of propofol (p=0,010), pentothal (p=0,034) and etomidate (p=0,004). The mean percentage of leukocyte concentration of propofol was 10687,503135,88/mm3, pentothal was 6975,001354,09/mm3 and etomidate was 5850,001105,83/mm3. Conclusions: There is a significant difference between propofol 2,5 mg/kg, pentothal 5 mg/kg and etomidate 0,3 mg/kg administration in increasing the leukocyte concentration. Propofol caused increase more significant concentration of leukocyte to pentothal and etomidate. Key words: propofol, pentothal, etomidate, leukocyte, general anesthesia