HUBUNGAN ANTARA EKSKRESI IODIUM URIN DAN EKSKRESI TIOSIANAT URIN DENGAN TOTAL GOITER RATE : Studi pada Anak SD di Kecamatan Bulakamba, Kabupaten Brebes Jawa Tengah

Abstract

Background: Health issue become a serious problem in Indonesia such as Iodine Deficiency Disorders (IDD) nowadays is more attended because of the effects i.e. goitre. Goitre is the one of several IDD spectrums. Iodine deficiency is not the only affector of IDD. The others like goitrogenic substances, for the example is thiocyanate can be a competitor with iodine in the tyroid hormone synthesis. The levels of endemicities for certain area is assessed based on the size alteration of tyroid gland (TGR). Urine Excretion Iodine can discribe the iodine intake by person. The most thiocyanate excretion is by the kidney, so that the levels can be checked in urine. It is important to know whether goitre is affected by iodine defficiency or thiocyanate consumption. Therfore this research aims to determine the relationship between UEI, Urine Thiocyanate Excretion and TGR. Methode : This was an analytical observational research with cross sectional design. Samples were 67 respondens. Simple random sampling were done with them. TGRs were secondary data from Dinas Kesehatan of Brebes Regency in 2010/2011. EIU was measured with Acid Digestion Methode with persultafe ammonium. Urine Thiocyanate Excretion was measured with spectrophotometri methode. The data were subjected to statistical analysis for correlation at 5% level of significance and regression, using SPSS 15.0 for Windows Results : UEI levels were 192,00 + 349 (346,00) μg/L. Urine Thiocyanate Levels were 0,36 + 4,64 (1,69) μg/mL. With the Spearman Test was showed that there was a relationship between UEI and TGR at 5% level of significance (p=0,001). There was no relationship between Urine Thiocyanate Levels and TGR at 5% level of significance (p=0,491). The R2 value was 0,022 using Regression Test for EIU and TGR. Conclusion : The UEI levels have a significantly relationship with TGR Keywords : IDD, TGR, UEI levels, Urine Thiocyanate Excretion levels