PERBEDAAN KEJADIAN LEUKOSITURI ANTARA PENDERITA PENYAKIT GINJAL KRONIK STADIUM V DENGAN DIABETES MELITUS DAN TANPA DIABETES MELITUS

Abstract

Background: Leukocyturia is one sign of infection or inflammation of the urinary tract. Chronic kidney disease (CKD) and diabetes mellitus (DM) is a chronic disease that can lead to several abnormalities in the immune system which allows an increased risk of infections, one of them is urinary tract infection. DM can also cause damage to microvascular complications that occur in various tissues including kidney glomerular capillary. Damage on the glomerular capillary may trigger the inflammatory response. Aim: To analyze differences of leukocyturia among patients with CKD stage V with DM and without DM. Methods: This study is an observational analytic study with case control design. Study sample was patients with CKD stage V in the dr. Kariadi General Hospital of Semarang during July 2011 – November 2011. Sample data obtained from patient’s medical records. Number of 66 samples consisted of 33 cases samples and 33 control samples. The data was analyzed using Chi-Square test. Results: Based on results of the chi-square test obtained p value < 0.05 ( p = 0.001) and the Odds Ratio (OR) of 6.250. Conclusion: There is a significant difference of leukocyturia among patients with CKD stage V with DM and non DM. Patients with CKD stage V with a positive history of DM had a 6.25 times likely to positively had leukosituri compared to patients without a history of DM. Keywords: Leukocyturia, Chronic Kidney Disease, Diabetes Mellitus.