HUBUNGAN KARAKTERISTIK (USIA DAN JENIS KELAMIN) DAN KADAR TRIGLISERIDA SERUM DENGAN KEJADIAN KARSINOMA KOLOREKTAL DI RSUP DR. KARIADI SEMARANG

Abstract

Background: Colorectal carcinoma ranked as 4th of the most deadliest cancer worldwide and 5th in Indonesia. The earlier research suggested that there was an association between age, sex, serum triglycerides levels, and the incidence of colorectal carcinoma. This study aimed to find out the association between characteristic (age and sex) and serum triglycerides leves with the incidence of colorectal carcinoma in Kariadi Hospital. Method: This was a case-control study. The samples were divided into two groups, the case and the control group. The case group included the patients was diagnosed with colorectal carcinoma in any stages between 2009-2011 while the control group included those who had the other diseases in digestive system. After selected by simple random sampling, the number of eligible samples according to the inclusion criterias was 30 for case and 78 for control. The Chi-Square and logistic regression test was used to analyse the data. Result: The Chi–Square test for serum triglycerides levels show that the value of p=0,312, with OR:1,643 (95% CI=0,642-4,326). For age logictic regression show that the value of significancy for 40-49, 50-59, ≥60 years age groups: p=0,095, p=0,267, p=0,287 respectively. The Chi–Square test for sex show that the value of p=0,006 (p<0,05), with OR: 3,641 (95% CI=1,4-9,468). Conclusion: serum triglycrides levels and age are negative risk factor colorectal carcinoma. Sex is significantly associated with the increased risk of colorectal carcinoma. Keywords: Serum triglycerides levels, age, sex, colorectal carcinoma xiv