HUBUNGAN DISLIPIDEMIA DENGAN KADAR UREUM DAN KREATININ DARAH PADA PENDERITA NEFROPATI DIABETIK

Abstract

Background: Diabetes Mellitus with Diabetic Nephropathy complications become one of the biggest causes of end stage renal disease in the world. The high levels of plasma lipid in people with diabetes play a role in the onset of atherosclerosis. It can lead to filtration process disturbances in glomerulus. Those renal function disorders were measured by Glomerular Filtration Rate (GFR), in which the decrease in GFR is followed by the increase in levels of blood urea and creatinine. Objectives: Demonstrate the relationship between dyslipidemia with the level of blood urea and creatinine in patients with Diabetic Nephropathy. Methods: The sort of this study is observational analytic with cross sectional approach. The subjects in this study amounted to 155 patients of Diabetic Nephropathy in the Dr. Kariadi General Hospital in the year 2010-2011 aged more than 18 years old. Data was obtained from patient’s medical records. The data was then analyzed by Mann Whitney test which is found a significant relationship if the value of p <0.05. Results: The results of statistical tests indicated there is a significant relationship between hypertriglyceridemia with levels of blood urea in patients with Diabetic Nephropathy (p = 0.016), but found no significant relationship between hypertriglyceridemia with blood creatinine levels (p = 0.089). While the other variables, namely hypercholesterolemia, the elevated levels of LDL-cholesterol, and the decreased levels of HDL-cholesterol showed no significant relationship with levels of blood urea and creatinine. Conclusion: There is a significant relationship between hypertriglyceridemia and the levels of blood urea in patients with Diabetic nephropathy with. Keywords: Dyslipidemia, Urea, Creatinine, Diabetic Nephropathy