HUBUNGAN ANTARA TERAPI KORTIKOSTEROID DENGAN KEJADIAN GLAUKOMA PADA ANAK DENGAN SINDROM NEFROTIK

Abstract

Background: Nephrotic syndrome is one of the most found kidney disease in children and corticosteroids are the primary form of therapy. Corticosteroids can increase intra-ocular pressure, in which increased intra-ocular pressure becomes a major riks factor for glaucoma. This study was aimed to association corticosteroid therapy with the incidence of glaucoma in children with nephrotic syndrome. Methods: This study was an observational analytic study with cross sectional design. Nephrotic syndrome samples were 23 children including 6 patients of steroid resistant nephrotic syndrome, 10 patiens of frequent relapse and 7 patiens of rare relapse. History of diagnosis of nephrotic syndrome and the use of corticosteroids obtained from medical records and data obtained from the examination diagnosis of glaucoma intra-ocular pressure using schiotz tonometry and optic nerve using Opthalmoskop. All samples were done before the examination consent inform the eye. Test statistical analysis used Chi-square and Fisher with the degree of significance p <0.05. Results: In this study found the incidence of glaucoma is 8.6% (2 patients) consisted of 16,6% (1 patient) steroid resistant nephrotic syndrome and 10% (1 patient) frequent relapses nephrotic syndrome. In this study found no positive the incident of glaucoma of rare relapse nephrotic syndrome Analysis of test results obtained the value of p= 1.000. Conclusion: There is no significant association corticosteroid therapy with the incidence of glaucoma in children with nephrotic syndrome. Keywords: corticosteroids, glaucoma, nephrotic syndrome, steroid resistance, frequent relapses, relapses are rare.