PENGARUH KEMORADIASI DENGAN CISPLATIN TERHADAP FUNGSI GINJAL PADA PASIEN KARSINOMA SERVIKS

Abstract

Background: Chemoradiation is one of the treatments of cervical carcinoma. Cisplatin is the most often used chemotherapy drugs. It has a nephrotoxic effect. Radiation on pelvic area can cause narrowing ureter that yields to impairment of renal function. Objective: To find out the effect of chemoradiation in cervical carcinoma patients with renal function, as shown from the differences of urea and creatinine levels before and after chemoradiation. Methods: This was quasi-experimental study with time series design. Data used were taken from medical records of patients with cervical carcinoma in RSUP dr. Kariadi Semarang, consisted of laboratory results of urea and creatinine levels before chemoradiation, after chemoradiation I, II, and III. Data were analysis using Friedman and Wilcoxon Signed Ranks test. Result: The mean urea levels of 28 patients in this study prior to chemoradiation, after I, II, III, and IV measurements were 24.18 mg/dL, 25.6 mg/dL, 23.36 mg/dL, and 21.25 mg/dL, respectively. Meanwhile, the mean creatinine levels were 0.82 mg/dL, 0.89 mg/dL, 0.87 mg/dL, and 0.82 mg/dL. Friedman test found significant differnces in levels of urea (p=0.013) and no significant differences in creatinine levels (p=0.353). In the Wilcoxon test of urea and creatinine levels obtained no significant differences between before and after chemoradiation I (p=0.386 and p=0.124), chemoradiation II (p=0.715 and p=0.156), and chemoradiation III (p=0.053 and p=0.509). Conclusion: There were no significant difference between urea and creatinine levels before and after I, II, and III chemoradiation. Thus, chemoradiation with cisplatin had no effect (safe) on renal function. Keywords: cervical carcinoma, chemoradiation, cisplatin, ureum, creatinine