The Synthesis of Carboxymethyl Amylose Grafted Polyacrylamide and Its Application in Drug Release Aspirin

Noor , Hidayati and Naila , Amanda and Karsono Samuel , Padmawijaya and Firman , Kurniawansyah and S, Sumarno (2012) The Synthesis of Carboxymethyl Amylose Grafted Polyacrylamide and Its Application in Drug Release Aspirin. In: International Conference on Chemical and Material Engineering 2012. ISBN : 978-602-097-281-7, September 12 – 13, 2012, , Grand Candi Hotel, Semarang Indonesia.

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Abstract

Polyacrylamide as a biocompetible polymeric material can be used in modifying drug release of aspirin. But limitations in absorbing water on this polymer can be covered with the addition of carboxymethyl amylose which is having more hydrophilic properties and may assist in crosslinking. The incorporation of carboxymethyl amylose and polyacrylamide were carried out by grafting methods and used polymerized with solution method. The results of the synthesis of carboxymethyl amylose-g-polyacrylamide are expected to have a more controlled release of aspirin which may minimize the side effect of delivery. The results of the synthesis of CMA-g-PAM and its formation were characterized by FTIR, XRD, swelling degrees (DS), and percent grafting efficiency (% GE). CMA-g-PAM products are expected to have more hydrophifilic and more biodegradable properties. The research show that CMA-g-PAM was succesfully synthesize by this method. The evident can be seen in XRD analysis from peak and graph observation. With the value of %GE found on the CMA-g-PAM DS 3 can reach up to 98.14% with concentration of NaOH 1.5 M, and a reasonable degree of swelling presented in the concentration of 2.5 M NaOH is 5699.52.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:carboxymethyl amylose grafted polyacryamide, drug release, percentage of grafting, polycrylamide, starch.
Subjects:T Technology > TP Chemical technology
Divisions:UNDIP Conference/Seminar > International Conference on Chemical and Material Engineering 2012
Faculty of Engineering > Department of Civil Engineering
Faculty of Engineering > Department of Civil Engineering
ID Code:36960
Deposited By:teknik kimia
Deposited On:16 Nov 2012 09:10
Last Modified:16 Nov 2012 09:10

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