The Synthesis of Carboxymethyl Amylose Grafted Polyacrylamide and Its Application in Drug Release Aspirin

Abstract

Polyacrylamide as a biocompetible polymeric material can be used in modifying drug release of aspirin. But limitations in absorbing water on this polymer can be covered with the addition of carboxymethyl amylose which is having more hydrophilic properties and may assist in crosslinking. The incorporation of carboxymethyl amylose and polyacrylamide were carried out by grafting methods and used polymerized with solution method. The results of the synthesis of carboxymethyl amylose-g-polyacrylamide are expected to have a more controlled release of aspirin which may minimize the side effect of delivery. The results of the synthesis of CMA-g-PAM and its formation were characterized by FTIR, XRD, swelling degrees (DS), and percent grafting efficiency (% GE). CMA-g-PAM products are expected to have more hydrophifilic and more biodegradable properties. The research show that CMA-g-PAM was succesfully synthesize by this method. The evident can be seen in XRD analysis from peak and graph observation. With the value of %GE found on the CMA-g-PAM DS 3 can reach up to 98.14% with concentration of NaOH 1.5 M, and a reasonable degree of swelling presented in the concentration of 2.5 M NaOH is 5699.52.