The Application of β-Cyclodextrin and Polyethylene Glycol 6000 in The Micronisation of Drug – Polymer Composite With Particle From Gas Saturated Solutions (PGSS) Method

Abstract

Particle design is presently a major development of supercritical fluida applications, mainly in the pharmaceutical and speciality chemical industries. Micronisation technology provides more possibilities to deliver drug in human body either through gastrointestinal track. That experiment has a purpose to create drug-polymer microparticle composite with Particles from Gas-Saturated Solutions (PGSS) technology. Different pressures (80-200 bar) and polymers (PEG 6000 and β cyclodextrin) were applied to get microparticle with narrow size distribution, discrit morphology and fast drug release profile. Ketoprofen-PEG 6000 and ketoprofen-β cyclodextrin was saturated with supercritical fluid in saturated vessel and the liquified time was 2 hours, then depressured the solution pass through nozzle as microparticles. The composite’s morphology is various by the effect of saturation pressure and type of polymer which used. Microparticle morphology indicate that higher saturation pressure create irregular microparticle product and on the contrary lower saturation pressure create sphere microparticle product. The average diameter of the particles obtained by PGSS at different conditions was about 0.83-7.74 μm and release profile of composite Ketoprofen-PEG 6000 was faster than ketoprofen-β cyclodextrin.