Effect of Phenylacetic Acid Addition on Productivity of Penicillium chrysogenum in Penicillin G Production Using Pilot Scale Reactor

Amila , Pramisandi, and Rofiq , Sunaryanto, and S, Suyanto, and Erwahyuni, Endang Prabandari (2012) Effect of Phenylacetic Acid Addition on Productivity of Penicillium chrysogenum in Penicillin G Production Using Pilot Scale Reactor. In: International Conference on Chemical and Material Engineering 2012. ISBN : 978-602-097-281-7, September 12 – 13, 2012, , Grand Candi Hotel, Semarang Indonesia.

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Abstract

Effect of penicillin’s precursor addition, phenylacetic acid (PAA), was done by addition of PAA in several concentrations in a pilot scale reactor batch culture to produce penicillin G with fungi Penicillium chrysogenum. Culture was analyzed by morphology observation and PAA was analyzed by HPLC. High concentration of PAA showed decreasing of biomassa and production of penicillin G that had contribution in increasing of cellular autolysis. However, Penicillium chrysogenum’s morphology analysis did not show significant effect in autolysis and decreasing of biomassa. Low concentration of PAA showed low production of penicillin G and low effect in biomassa or autolysis. Those effects of PAA addition need an exploitation to induce the phenomenon in Penicillium chrysogenum’s culture.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:penicillin G, Penicillium chrysogenum, phenylacetic acid, reactor
Subjects:T Technology > TP Chemical technology
Divisions:UNDIP Conference/Seminar > International Conference on Chemical and Material Engineering 2012
Faculty of Engineering > Department of Chemical Engineering
Faculty of Engineering > Department of Chemical Engineering
ID Code:36934
Deposited By:teknik kimia
Deposited On:14 Nov 2012 23:21
Last Modified:14 Nov 2012 23:21

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