THE AMINE GROUP PROTECTION OF L-CYSTEINE AND L-VALINE THROUGH THE FORMATION OF FORMAMIDE

Jujur Wibawa, Pratama and Ismiyarto, Ismiyarto (2002) THE AMINE GROUP PROTECTION OF L-CYSTEINE AND L-VALINE THROUGH THE FORMATION OF FORMAMIDE. Jurnal Kimia Sains dan Aplikasi, 5 (2). ISSN 1410-8917

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Abstract

The reactions of amine group protection of L-valine and L-cysteine have been accomplished in this research with formic acid protecting agent to form formamide L-valine and formamide L-cysteine respectively. This two formamides of the amino acid would be used to synthesize 6-amino penicillanic acid (6-APA), a very important key intermediate for a new β-lactame antibiotic. The reaction was carried out in a round bottom flask of a refluks set at 50-60oC for 60-90 minutes. After the time was over, the liquid excess was separated employing Buchii rotary evaporator and then it was recrystalized with ethanol for pure crystal. The crystal produced from L-valine treatments melted at 153-154oC, and those from L-cysteine melted at 129-131oC. The crystals each gave one mark on a 60F254 silica gel TLC plate and their IR spectrum each indicated that the reactions of those was successfull to be done, and each formed formamide L-valine and formamide L-cysteine respectively.

Item Type:Article
Uncontrolled Keywords:protecting agent (blocking agent); formamide L-valine; formamide L-cysteine
Subjects:Q Science > QD Chemistry
Divisions:Faculty of Science and Mathematics > Department of Chemistry
ID Code:3464
Deposited By:Jurusan Kimia FMIPA
Deposited On:13 Jan 2010 12:55
Last Modified:13 Jan 2010 12:55

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