ASOSIASI GENOTIP APOLIPOPROTEIN E DENGAN FUNGSI KOGNITIF PADA PASIEN PASCA STROKE ISKEMIK

Abstract

Background : The Apolipoprotein E (APOE) gene affects cognitive function after ischemic stroke through the role of its phenotype (apoE protein) in repairing neurons and glia. APOE ε4 allele genotype effects is less profitable than other genotypes. The relationship between APOE genotype and cognitive function after stroke has not been consistent. Purpose : analyze the association between ApoE genotype with cognitive function in post ischemic stroke patients. Method : cross sectional study from August-November 2011 with consecutive sampling in post ischemic stroke patients at RSUP Dr. Kariadi Semarang. Examination of cognitive function domain using CERAD modification and CDR, laboratory examinations of blood, and ApoE genotyping by PCR-RFLP. Results : There were 31samples of post ischemic stroke patients. The most common of APOE allele genotypewas ε3 /3 (45.2%). Vascular dementia was found in 8 subjects (25.8%), VCIND in 9 subjects (29.0%), and VCI in 17 subjects (54.8%). There were no significant relationships between the of APOE genotype alleles with dementia, VCIND, or VCI. The most common impaired cognitive domains was executive functions and language, found in 9 subjects (29%), followed by visuoconstructional disruption in 7 subjects (22.6%), attention (6 subjects; 19.4%), and memory disturbances (4 subjects ; 12.9%). There was a significant differences in executive function among subjects with the APOE ε4 alleles genotype compared with non-ε4 (P=0,035). There were no significant differences in attention, memory, language, and visuoconstruction between subjects with the APOE ε4 allelescompared with non-ε4 alleles. Conclusion : APOE genotype was not associated with vascular dementia, VCIND, andVCI. APOE ε4 allele genotype was associated with poorer executive function in patients after ischemic stroke.There was no relation between APOE genotype and attention, memory, language, and visuoconstruction. Keywords : APOE genotype, cognitive function, post ischemic stroke