Hubungan antara Kadar Low Density Lipoprotein-Cholesterol (LDL-C) dengan Kejadian Gangguan Kognitif Pada Penderita Pasca Stroke Iskemik

Abstract

Background: Stroke is a disease that can lead to disability, including impaired cognitive function. One of the atherogenic risk factors clinically recognized as the precursor of atherosclerosis is the increased LDL-Cholesterol concentration. Previous studies analyzing LDL Cholesterol relationship with impaired cognitive function showed controversial results Objective: To prove the association between LDL- Cholesterol concentration with impaired cognitive function in post-ischemic stroke patients. Method: Cross sectional, study subjects: patients with post-ischemic stroke in the neurological clinic Dr. Kariadi Hospital Semarang, the number of subjects: 42 people. Independent variables: levels of LDL-C, the dependent variable: impaired cognitive function as measured by the method of MoCA-Ina; confounding variables: age, sex, history of diabetes, history of hypertension, smoking, total cholesterol, HDL-C, triglycerides, lacunar infarct and cerebral atrophy. Hypotesis testing: t-test, Mann-Whitney test, chi-square test, and multivariate logistic regression test. Result: Impaired cognitive function occured in 32 subjects (76,2%). There was no significant difference in means variables between groups of study subjects with impaired cognitive function, and without impairment of cognitive function (p >0.05). There was no association between LDLC levels with the incidence of impaired cognitive function. Conclusion: No proven relationship exists between LDL-C levels with the incidence of impaired cognitive function. Keywords: LDL- Cholesterol concentration, cognitive impairment, post- ischemic stroke.