PENGARUH PEMBERIAN SIMUNOX TERHADAP JUMLAH SEL T CD4+ MANUSIA SEHAT

Abstract

Background: CD4+ T cells are also called T helper cells that help phagocytic process ingested microbes and help B lymphocytes to produce antibodies, they can be stimulated by immunomodulators, one of which is from herbs. Simunox is a modification from Tolak Angin with an addition of Phyllanti herba, where in previous study has been proven to increase lymphocytes proliferation dan phagocytic function in Swiss mice. This study was designed to know if administration of Simunox can increase CD4+ T cells count on healthy individuals. Methods: This was a true experimental research with randomized pretest – posttest control group design using 50 healthy individuals which were divided into controlled group and treated group. The treated group was administered with Simunox for 7 days while the controlled group was administered with placebo. The data was analyzed with Shapiro-wilk test and paired T-test, and to compare the difference between pre and post in controlled and treated group was using independent T-test. Result: Administration of Simunox to the treated group was not significantly increase CD4+ T cells count. The result of paired T-test showed p=0,144. In controlled group, mean CD4+ T cells count were decreased, but the difference between pre and post administration in treated and controlled group did not show any significancy (p=0,262). Conclusion: Administration of Simunox could not significantly increase CD4+ T cells. The difference of pre and post administration in treated and controlled group showed insignificancy.