HUBUNGAN ANTARA BESI SERUM DAN SATURASI TRANSFERIN DENGAN KADAR HEPSIDIN PADA CARRIER TALASEMIA-

Abstract

Background: Genetic disease such as hemolytic anemia, especially thalassemia carriers with thalassemia generally less known by the common people, but prevalence rate high enough in the cause of mortality and morbidity. Thus, the use of excessive iron suplementation leading to iron overload. Iron load is governed by hepcidin. Hepcidin have a role in regulation of iron homeostasis and erytrhropoeisis activity in the human body. Therefore this study aims to determine the association between iron serum and transferrin saturation with hepcidin levels in thalassemia beta carriers. Methods: The study design was cross sectional analytic observational approach. Sampling by consecutive sampling from primary data in the laboratory departement of clinical pathology in RSUP.Dr. kariadi and PMI city of Semarang. 26 respondents do as much as 6 ml of blood sampling. Meassurement hepcidin levels using an ELISA reader based on the wave spectrophotometry, for the meassurement of status while iron and transferrin saturation using automatic analizer. Analysis of the data is processed using a computer program with level of significance accepted when p>0,05 and the calculation of numerical data. Results: The study sample involved 26 respondents. Spearman test results showed no significant relationship exists between the levels of serum iron with hepcidin levels (p= 0,071, r=0,077), and transferrin saturation with hepcidin levels (p= 0,021, r=0,373) in thalassemia beta carriers. Conclusions: The hepcidin levels not have a significant association with serum iron and transferrin saturation in beta thalassemia carriers.