PENGARUH PEMBERIAN INDUKSI ANESTESI ETOMIDATE 0,2 mg/kgBB TERHADAP KADAR GULA DARAH

Abstract

Background: One of the effects of etomidate is pressing synthesis of steroids in the adrenal cortex that reversibly inhibits 11β hydroxylase. The effects of adrenal suppression causing hypoglycemia are needed by patient. It can supress the increasing of blood glucose levels resulting from stress respons to surgery. This study to prove the effects of etomidate that cause decreasing on blood glucose levels Methods: Design of this study is pre and post test one group design on 15 patients who are undergoing surgery with general anesthesia based on inclusion and exclusion criteria. And then blood glucose levels before, 2 hours, and 6 hours after induction of etomidate0,2 mg/kgbw was examined. All data were analyzed by paired T-test. Result: Blood glucose of etomidate 0,2 mg/kgbw were significantly different between before and 2 hours after induction (p=0.002), 2 hours and 6 hours after induction (p=0,04). But blood glucose between before and 6 hours after induction is not significant (p=0,66). Mean of blood glucose levels before induction is 103,93 mg/dl, 2 hours after induction decrease to 94,8 mg/dl, and 6 hours after induction flare up to 102,07 mg/dl. Statistically, etomidate decreasing blood glucose but still in normal. Conclusion: Etomidate 0,2mg/kgbw were statistically significant in decreasing blood glucose on 2 hours and 6 hours after induction but still in normal.