KARAKTERISTIK PASIEN HIV/AIDS DENGAN KANDIDIASIS OROFARINGEAL DI RSUP Dr. KARIADI SEMARANG

Abstract

Background: HIV/AIDS epidemic in Indonesia is one of the fastest growing in Asia. As previous study in RSUP Dr. Kariadi Semarang showed that the most common opportunistic infection on HIV/AIDS patients was oropharyngeal candidiasis, which was 79%. Oropharyngeal candidiasis is a mucosal opportunistic infection moslty attributed to Candida albicans, but can also be caused by any other species, i.e Candida glabrata, Candida tropicalis, and Candida krusei. Aim: To know the characteristics of HIV/AIDS patients with oropharyngeal candidiasis in RSUP Dr. Kariadi Semarang. Materials and Methods: This was an observational descriptive study on HIV/AIDS patients with oropharyngeal candidiasis who were hospitalized in Internal Medicine Ward RSUP Dr. Kariadi Semarang during December 2010 -May 2011. The diagnostic criteria of oropharyngeal candidiasis were obtained from microbiological identification (gram stained, culture, germ tube and fermentation). Results: Fourty two HIV/AIDS patients with oropharyngeal candidiasis consist of 29 males (69%), mostly between 30-39 years old, majority were labors and private workers (21,43%), married (88,09%), underweight (52,38%), CD4 <50 cells/µl (78,57%), and came from Semarang. Microbiologic cultures from 40 samples showed candida colonies of which 75% of them grew >300 candida colonies and were 55% non C. albicans, comprised of 15% C. stellatoidea, 15% C. tropicalis, 12,5% C. parapsilosis, 7,5% C. krusei, 2,5% C. glabrata, and 2,5% C. guilliemondia. Conclusions: We obtained HIV/AIDS patients characteristics with mostly CD4 <50 cells/µl, cultures from 40 microbiological samples showed candida colonies. From 40 candida colonies 55 % (22 isolat) showed non C. albicans.