FAKTOR-FAKTOR YANG MEMPENGARUHI TERJADINYA RESISTENSI RIFAMPICIN DAN / ISONIAZID PADA PASIEN TUBERCULOSIS PARU DI BKPM SEMARANG

Abstract

Background: Multiple resistant (Multidrugs Resistant Tuberculosis / MDR TB) is the biggest problem of the global TB prevention and eradication. The incidence of MDR TB is likely to increase annually. Indonesia is a country that high burden of TB disease,which is found in many new TB patients and who are treated diagnosed with MDR TB. Acquired resistance to rifampicin and isoniazid are the most. This study aims to determine and find the most influential factors on the occurrence of resistance to rifampicin and or isoniazid. Method: This study is a cross-sectional study with descriptive analytic design, using the TB patients as the study sample. The data is secondary data taken from BKPM Semarang medical records during the years 2005 – 2010. Selection of samples using random sampling method with inclusion and exclusion criteria. A total of 99 selected samples were recorded risk factor data variables. The data described in table form, performed chi square tests, prevalence ratios and logistic regression analysis with SPSS for Windows 17. Result: Chi Square Test with α=0,05, CI95%, P=0,51 and d=10% indicates that all variables (education, PMO, treatment delay, HIV-AIDS, duration of therapy and the use of FDC drug) had no effect (p>0,05) to the occurrence of resistance to rifampicin and or isoniazid. Logistic regression analysis also showed no significant results (p>0,05) for all variables tested. Conclusion: All variables were tested is not a factor which influencing the occurrence of resistance to rifampicin and or ioniazid.