EFEK FLUVASTATIN TERHADAP ALKALI FOSFATASE SERUM PADA TIKUS WISTAR YANG TERPAPAR ASAP ROKOK

Amalia, Fitri and Johan, Andrew (2011) EFEK FLUVASTATIN TERHADAP ALKALI FOSFATASE SERUM PADA TIKUS WISTAR YANG TERPAPAR ASAP ROKOK. Undergraduate thesis, Faculty of Medicine.

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Abstract

Background: Cigarette smoke includes free radicals that cause inflamation process which can increase inflamation markers such as alcaline phosphatase (ALP) serum. Fluvastatin has anti-inflammatory effect by inhibiting the secretion of the enzyme myeloperoxidase (MPO) secreted by activated neutrophils which produce serum ALP serum and decreased levels of inflammatory cytokines TNF-α, IL-1, IL-8, and total leukocytes and neutrophils in sepsis rat. Fluvastatin also has a pro-inflammatory effects that increase the levels of cytokine transforming growth factor-beta (TGF-β) resulting in activation of neutrophils. This study aims to determine the effect of serum ALP levels. Methods : This study is an experimental study with pre and post test only control group design. Rats that had undergone adaptation for 1 week were divided rendomly into 3 groups each 6 rats and induced by cigarette smoke. KA was given fluvastatin 5mg/kgBW, KB was given fluvastatin 10mg/kgBW, and K without fluvastatin per-oral. AlP levels is checked by spctrofotometry (unit/cc) before an after exposure by 2 cigarettes/days in 4 weeks. Normal distributes data were analized by One Way Annova test and data that were not normally distributed were analized by the Krusskal Wallis test Result: Difference in serum ALP levels before and after exposure to cigarette smoke K: 226.8; KA: 180.17; KB: 378.0 with p> 0.05 between groups C and KA and p <0.05 between KB and K and KA and KB. Conclusion: Fluvastatin can not inhibit the increase of ALP levels in wistar rats that were given exposure to 2 cigarettes/days for 4 weeks. Fluvastatin 5mg/kgBW had mean levels of serum ALP is smaller than the fluvastatin group and the control group 10mg/KgBB

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > R Medicine (General)
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:33007
Deposited By:Ms Lutfiatun Heni
Deposited On:06 Feb 2012 11:03
Last Modified:06 Feb 2012 11:03

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