PENGARUH DECOCTA BUAH PARE ( Momordica charantia L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS WISTAR YANG DIBERI BEBAN GLUKOSA

Abstract

Background : bitter melon fruit contain charantin which has stimulates beta pancreas cell, polipeptida-p which similary insulin secretion, and glikosida which increase preasure of intestinal wall. The purpose of this experiment is to proof that the bitter melon fruit can decrease blood glucose level by giving decocta of bitter melon fruit on pre-loaded wistar rats. Method : The study was conducted by employing a complete Randomized Post Test Control Group Design in 25 local male wistar rats, weight 200-250 gr, and 3-4 month old, which was divided into 5 different groups. The blood glucose level was measured using glucometer One Touch®UltraTM at 0, 30, 60, 90, and 120 minute after the glucose tolerant was given. The data was processed using SPSS for Windows Release 15. Conclusion : Decocta of bitter melon fruit at 2,5 ml/200grW; 5 ml/200grW; 10ml /200grW doses can decrease the pre-loaded wistar rats’ blood glucose level. However, the hypoglycaemic effect of decocta of bitter melon fruit at the doses above shows smaller reduction of blood glucose level compared to glibenclamid at 0,126 gr/ 200grW dose.