PENGARUH PEMBERIAN ETOMIDATE 0,3 mg/kgBB INTRAVENA TERHADAP AGREGASI TROMBOSIT

Abstract

Background :Preoperative bleeding is aserious and common problem in surgery. Induction anesthetic agent usage is known for the inhibition of platelet aggregation. Objective :To see the changes of platelet agregation after the injection of Etomidate 0,3mg/kgBM. Method :An experimental study on 20 patients who received general anasthesia. Sample received Etomidate as the induction anesthetic. The speciments are taken before the injection of Etomidate and 5 minutes after injection. All specimens were taken to the Clinical Pathology Laboratory for Platelete Agregation testing. Statistical analyses were performed using paired t-test ( with level of significant is P<0,05). Result :The patients characteristic and variables data to be compared were normally distributed. The changes of platelete agregation after the injection of Etomidate 0,3mg/kgBM is not significant. The platelete agregation before the injection Etomidate is 73,45 ± 7,33 and the platelete agregation after the injection of Etomidate is 66,07 ± 8,28 with P=0,089. Conclution :Etomidate is unsignificantly changes the platelete agregation. Keywords :Etomidate, ADP, Platelete agregation.