KORELASI ANTARA LAMA DEMAM DENGAN KADAR IgM DAN IgG ANAK YANG MENDERITA DEMAM BERDARAH DENGUE

Abstract

Background: The production of antibody increases 20 times higher when human gets fever compared at normal temperature. Antibody that formed, IgM and IgG, have important role in immunopathogenesis of DHF. These can eliminate virus so that ease the course of the disease. The aim of this research was to prove the correlation between length of fever and IgM and IgG level. Methods: This observasional research was conducted with medical record of DHF patients who were treated at Dr. Kariadi Hospital in December 2010-May 2011. Research subjects were 26 children aged 3-14 years old. The length of fever were known from family anamnesis data and measurement results during treatment period in Dr. Kariadi Hospital. Anti dengue IgM and IgG levels derived from serologic data that used dipstick ELISA. Spearman’s correlation test was permormed to determine the correlation between variables. Results: The average of length of fever on research subjects 5,3 (± 2,26) days while the average levels of IgM 2,7 (± 0,55) and IgG 2,8 (± 0,49). Spearman’s correlation test showed that correlation between length of fever and IgM level was negative one with moderate correlation strength (r = -0,46; p = 0,02) whereas length of fever did not correlate with IgG level (r = -0,26; p = 0.2) and ratio of IgM/IgG (r = -0,25; p = 0,2). Conclusion: The length of fever didn’t has correlation with IgG but it had negative correlation with IgM level.