Fluoroquinolone-resistant Escherichia coli, Indonesia

Kuntaman, Kuntaman and Lestari, Endang Sri and Severin, Juliëtte A. and Kershof, Irma M. and Mertaniasih, Ni Made and Purwanta, Marijam and Hadi, Usman and Johnson, James R. and Belkum, Alex van and Verbrugh, Henri A. (2005) Fluoroquinolone-resistant Escherichia coli, Indonesia. Emerging Infectious Diseases, 11 (9). pp. 1363-1369. ISSN 1080-6059

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Official URL: http://www.cdc.gov

Abstract

In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.

Item Type:Article
Uncontrolled Keywords:Escherichia coli
Subjects:R Medicine > R Medicine (General)
Q Science > QR Microbiology > QR355 Virology
Q Science > QR Microbiology > QR180 Immunology
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:3256
Deposited By:Mr. Kedokteran Admin
Deposited On:11 Jan 2010 13:25
Last Modified:11 Jan 2010 13:25

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