Hubungan Jumlah Neutrofil Absolut dengan Mortalitas pad Stroke Iskemik Akut dengan Komplikasi Pneumonia

Abstract

Background: Acute ischemic stroke patients with pneumonia experienced inflammation reaction which induces neutrophil invasion to lung tissue as a defense mechanism towards infection. Absolute neutrophil count is suspected to relate with mortality of acute ischemic stroke patients with pneumonia. Methods: This cohort observational perspective research was performed from November 2010 until April 2011 on 34 acute ischemic stroke patients with pneumonia at Dr. Kariadi Hospital Semarang. Correlation analysis was done to investigate whether absolute neutrophil count (ANC) is correlated with mortality. Correlation analysis was also performed to explore whether ANC is correlated with NIHSS score at 7th day post diagnosis of pneumonia on surviving patients. Cut off value 7600/μL from previous research was chosen to determine risk relative of ANC towards mortality. Results: Absolute neutrophil count (ANC) was positively correlated with mortality and showed tendency towards mortality among acute ischemic stroke patients with pneumonia. ANC was also positively correlated with NIHSS score among surviving patients. Cut off value 7600/μL from previous research yielded sensitivity 85,7%; specificity 40,7%; with insignificant p value 0,203 and rho 0,224 in this research. Conclusions: Absolute neutrophil count (ANC) is positively correlated with mortality of acute ischemic stroke patients with pneumonia although insignificantly. It was correlated with neutrophil role in inflammatory response, in which overresponse could hamper mortality and neurological deficit state of patients that measured by NIHSS score. Keywords: Absolute neutrophil count (ANC), acute ischemic stroke, pneumonia, mortality.