GENERAL MOVEMENTS PADA BAYI DENGAN RIWAYAT HIPERBILIRUBINEMIA GENERAL MOVEMENTS IN NEWBORN HYPERBILIRUBINEMIA

Abstract

Background. Early detection to predict neurodevelopmental disorders in early infancy is difficult. Hyperbilirubinemia is one of the major cause of neurodevelopmental disorders leads to developmental delayed. General movements(GMs) is a sensitive tool to evaluate brain function in young infants. Objective. To determine the risk factor of neonatal hyperbilirubinemia to predict abnormal general movements. Method. A Cohort research was conducted in 44 neonates in Dr Kariadi Hospital in September 2009-Februari 2010, 22 neonates with BIS > 12 mg/dl and 22 neonates with IBS < 12 mg/dl, both taken with consecutive sampling method, after three months the infants were recorded according to Precthl method. Each recording was analyzed by means of Gestalt perception of the expert. Grouping to normal and abnormal GMs based on Likert scale. Abnormal GMs if the score was ≤ 5. Chi-square test, Receiver Operating Curve and multivariat logistic regression analysis were done. Results. Mean IBS level of subject with abnormal GMs risk was 15,6 mg/dL, 15 (34,09%) subjects had abnormal GMs. Receiver Operating Curve (ROC) showed IBS level could be used as outcome predictor for abnormal GMs in young infants, with IBS cut-off point 12.67 mg/dL. IBS level > 12 mg/dL were risk factor 28,4x leads to abnormal GMs. There was a significant correlation between neonatal BIS Level and the risk of abnormal GMs in young infants. Conclusion. Neonatal hyperbilirubinemia were risk factor 28,4x leads to abnormal GMs and the IBS cut-off point is 12.67 mg/dL. Key word : general movements, hyperbilirubinemia.