Sintesis senyawa 3-Metoksi-4 hidroksikalkon dari vanilin dan Asotofenon

Madiyono , Madiyono (2002) Sintesis senyawa 3-Metoksi-4 hidroksikalkon dari vanilin dan Asotofenon. Undergraduate thesis, FMIPA UNDIP.

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Abstract

Penelitian sebelumnya melaporkan bahwa senyawa kalkon dari reaksi vanilin dan asetofenon yang dilakukan dengan metode Kohler-Chadwell pada suhu kamar temyata tidak terbentuk, walaupun reaksi dilakukan selama 24 jam. Pada penelitian ini telah dilakukan sintesis senyawa 3-metoksi-4- hidroksikalkon dengan bahan away vanilin dan asetofenon dengan metode Kohler¬Chadwell yang dimodifikasi yaitu dengan rnelakukan reaksi pada suhu 60 °C dalain NaOH 60 % . Optimasi produk dilakukan dengan variasi waktu 3, 4, 5, 6, 7, 8 jam. Di sisi lain, pengaruh suhu terhadap reaksi yang terjadi dipelajari dengan variasi 30, 40, 50, 60, 70, 80°C. Reaksi dilakukan berdasarkan mekanisme Claisen-Schmidt. basil eksperimen menunjukkan bahwa rendemen produk murni yang dapat dipisahkan setelah dilakukan reaksi dalam NaOH 60 % pada suhu 60 °C selama 7 jam yaitu 92,01 %. Disarnping itu, basil variasi suhu reaksi menunjukkan bahwa produk cenderung bertambah dengan meningkatnya suhu dan mencapai kondisi optimal pada suhu 70 °C. Previous research reported that 3-metoxy-4-hydroxychlcone could not be formed using Kohler-Chadwell method, although reaction has been carried out during 24 hours. In this research, synthesis of 3-rnetoxy-4-hydroxychalcone has been conducted using modified Kohler-Chadwell method. Reaction was carried out in NaOH 60% at 60°C as long as 3, 4, 5, 6, 7, 8 hours sequently. Besides, the effect of temperature was studied at 30, 40, 50, 60, 70, 80 °C. Vanilin and acetophenone take part as raw materials. The result showed that the yield of pure product which cauld be separated after performing the reaction in NaOH 60 % at temperature 60 °C during 7 hours was 92.01 %. In other hand, modification of the reaction condition in various temperature indicated that the higher temperature used the higher product formed. Optimum temperature of the reaction was 70 °C.

Item Type:Thesis (Undergraduate)
Subjects:Q Science > QD Chemistry
Divisions:Faculty of Science and Mathematics > Department of Chemistry
ID Code:30834
Deposited By:Mr UPT Perpus 1
Deposited On:08 Nov 2011 07:06
Last Modified:08 Nov 2011 07:06

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