PENGARUH PENAMBAHAN ALPHA LIPOIC ACID TERHADAP PERBAIKAN KLINIS PENDERITA POLINEUROPATI DIABETIKA The Influence of Alpha Lipoid Acid Suplementation on The Clinical Improvement in Diabetic Polyneuropathy Patients

Prasetyo, M. Agus (2011) PENGARUH PENAMBAHAN ALPHA LIPOIC ACID TERHADAP PERBAIKAN KLINIS PENDERITA POLINEUROPATI DIABETIKA The Influence of Alpha Lipoid Acid Suplementation on The Clinical Improvement in Diabetic Polyneuropathy Patients. Masters thesis, Diponegoro University.

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Official URL: http://www.mbiomedik.undip.ac.id/

Abstract

Background: Alpha lipoic acid is an antioxidant known to inhibit free radicals and affect insulin sensitivity. The study was aimed to determine the clinical improvement of diabetic polyneuropathy patients with alpha lipoid acid 600 mg/day supplementation to standard therapy. Methods: A double-blind randomized controlled trial of patients with diabetic polyneuropathy in type 2 diabetes whom were clinically diagnosed using DNE, DNS scores, and VAS score for pain. Subyek were 44 in patients polyneuropathy diabetic , divided into non treatment group who received standard therapy + placebo (n = 21) and treatment group who received standard therapy + alpha lipoic acid 600 mg / days (n = 23) for 12 weeks. Clinical assessments were done based on DNE scores, DNS scores and VAS scores at week 0, 4, 8 and 12. The alterations of score were analyzed within and among groups. Data were analyzed using X2,T test, Mann-Whitney,Wilcoxon and Friedman test . Results: There was no significant difference in the reduction of DNS and DNE scores in treatment groups compared with non-treatment group (p> 0.05). Decrease of VAS score in the treatment group was better than non treatment (p<0,05). The mean VAS score of treatment v.s non-treatment group treatment weeks 4, 8 and 12 are: 3.7 vs. 4.3; 2.7 vs. 4.0 and 2.1 vs. 3.4. Conclusion: Supplementation with alpha lipoic acid 600 mg/day to the standard therapy gives better improvement of pain intensity in diabetic polineuropathy based on VAS score. Key words: diabetic polyneuropathy - alpha lipoic acid - clinical improvement.

Item Type:Thesis (Masters)
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:30687
Deposited By:Mr. Magister Biomedik Admin
Deposited On:04 Nov 2011 12:58
Last Modified:04 Nov 2011 12:58

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