COMPARING THE EFFECT OF CLOMIPHENE CITRATE VERSUS LETROZOLE ON FOLLICLE, ENDOMETRIUM AND MUCUS CERVIX Randomized Controlled Trial in Infertile Women with Anovulation WHO II

Abstract

Objective : To compare the follicle diameter, the number of mature follicle, quality of endometrium, quality of mucus cervix and a success rate of ovulation between clomiphene citrate (CC) and letrozole. Design : Randomized controlled double blind trial was done parallel design non matching from September 1st, 2007 until January 31st, 2008 in Dr. Kariadi General Hospital Semarang. Fourty infertile women with anovulation WHO II were eligible as subject, divided into 20 subyect each according block randomisasion. Dependent variables were CC (50mg/day) and letrozole (2,5mg/day) given on day 3–7 of the menstrual cycle. Independent variable were the follicle diameter, the number of mature follicle, quality of endometrium, quality of mucus cervix and a success rate of ovulation that comparable between groups. Analysis was done using chi square, t test and Mann Whitney comparing independent sample test and Lambda and Spearman correlation with statistically significance if p<0,05. Result : The patient’s characteristics were the same between two group. The follicle diameter were the same between two group (CC group is 21,65 (3,58) mm and letrozole group is 19,8 (7,03) mm. Eighteen subject on CC group had mature follicle, 4 had multiple mature follicle. Single mature follicle was found in 13 subject on letrozole group. The number of mature follicle were the same between the two group (p=0,09). Quality of endometrium (p=0,03) dan quality of mucus cervix (p=0,03) were significantly better on letrozole group than CC group (good quality of endometrium and good quality of mucus cervix were 14 vs 6). All subject on CC group and 18 subject on letrozole group had ovulation (p=0,49). Conclusion : There were no significant difference on the follicle diameter, the number of mature follicle and the success rate of ovulation, but the quality of endometrium and mucus cervix wer better on letrozole group than CC group.