PENGARUH PEMBERIAN EKSTRAK PHALERIA MACROCARPA TERHADAP INDEKS APOPTOSIS SEL ADENOKARSINOMA MAMMA DAN PERKEMBANGAN MASSA TUMOR PAYUDARA MENCIT C3H

Suryanto, Teguh (2007) PENGARUH PEMBERIAN EKSTRAK PHALERIA MACROCARPA TERHADAP INDEKS APOPTOSIS SEL ADENOKARSINOMA MAMMA DAN PERKEMBANGAN MASSA TUMOR PAYUDARA MENCIT C3H. Masters thesis, Diponegoro University.

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Official URL: http://mbiomedik.undip.ac.id/

Abstract

Background: Polyphenols in Phaleria macrocarpa (Mahkota Dewa) which stimulate Interferon- production in some immunocyt population can increase Cytotoxic T-Lymphocyt (CTL) and Natural Killer Cell (NK-Cell) activity; which can be recognized from apoptotic index as a response to malignant cells and resistancy of clinically tumor development which can be measure from tumor growth diameter. Objective: To prove the difference of apoptotic index and tumor diameter size and analyze the correlation between apoptotic index and tumor diameter size. Material and method: A randomized post test only control group design on 20 C3H-mice were divided into 4 treatment groups. The first group is control group, group-1 was administered with 0,035mg Phaleria macrocarpa/day, group-2: 0,0715mg/day, group-3: 0,14mg/day. After complete tumor cell inoculation, diameter size of tumor before-treatment was measured. All of group were treated for 3 weeks, then measured before and after-treatment tumor diameter size and evaluate the tumor apoptotic index. A One Way ANOVA Test is used to evaluate the difference of before-and-after tumor diameter size and tumor apoptotic index. Pearson’s Correlation test was performed to analyze the correlation between tumor apoptotic index and tumor diameter size. Result: There is significantly difference of tumor size among groups, and significantly negative correlation (p<0,001) between tumor apoptotic index and tumor diameter size, with correlation coefficient -0,773. Conclusion: The reduction of tumor was start at 0,035mg/day administration of Phaleria macrocarpa extract, and there is significantly negative correlation between tumor apoptotic index and tumor diameter size. Key words : Phaleria macrocarpa, apoptotic index, tumor diameter, adenocarcinoma mammae

Item Type:Thesis (Masters)
Subjects:R Medicine > RD Surgery
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:29412
Deposited By:Mr. Magister Biomedik Admin
Deposited On:20 Sep 2011 12:37
Last Modified:20 Sep 2011 12:37

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