JUMLAH NEUTROFIL ABSOLUT SEBAGAI INDIKATOR KELUARAN STROKE ISKEMIK

Abstract

Background: In acute ischemic stroke, inflammation reaction occurs then mobilizes neutrofil cells as the first leucocytes coming through ischemic area. Absolute neutrofil count of the peripheral blood at 10-72 hours of onset can be expected as indicator for severity of disease with evaluation of NIHSS scoring system on the first and seventh day and also by altering scores of days in between Research Method: This was observational longitudinal prospective study done periodically in the period of December 2006 to July 2007 at RSUP. Dr. Kariadi Semarang. Absolute neutrofil count and evaluation of NIHSS score at 10-72 hours of the onset were performed to 41 patients having ischemic stroke attack for the first time. At day 7 of the onset these procedures were repeated thoroughly. Development of the neurological deficit was acknowledged based on score differences found in the first measurement compared to the ones found at day 7 of the onset. Mean average test was carried out on the first and second neutrofil count. Correlation test was also done to seek out any association between first absolute neutrofil count and variety of patient’s outcome. Result: There were significant differences between absolute neutrofil count on the (p=0.03) , mean average NIHSS score on the first day admission of the patient (11.7) and day 7 of the onset (8.7) ( p<0.001). Absolute neutrofil count on the first day of admission was sensitive enough to envisage neurological deficit developed after day 7 of the treatment (with sensitivity 80.1%) however it was not specific enough ( with specifity = 40%). Total amount of absolute neutrofil count at the admission as indicator the development of neurological deficit after Conclusion: Absolute neutrofil count at 10-72 hour onset employed good indicator for the outcome of acute ischemic stroke attack. Nevertheless other examinations were still needed to augment the accuracy of indicator. With absolute neutrofil count ischemic stroke attack.