PENGARUH VAKSINASI BCG TERHADAP KADAR IgE-TOTAL DAN PERBAIKAN GEJALA KLINIK RINITIS ALERGI

Nurada, I Gusti Ketut (2006) PENGARUH VAKSINASI BCG TERHADAP KADAR IgE-TOTAL DAN PERBAIKAN GEJALA KLINIK RINITIS ALERGI. Masters thesis, Diponegoro University.

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Official URL: http://mbiomedik.undip.ac.id/

Abstract

Background: Bacille Calmette-Guerin (BCG) vaccination induces Th1 immune responses. Th1 and Th2 cells are reciprocally regulated. BCG vaccination was hypothesized as a downregulator of IgE production so that improving Th2 driven diseases including allergic rhinitis. Objective: This study investigated the effect of BCG vaccination to total IgE level and clinical improvement, and the relationship between total IgE level and clinical symptoms of allergic rhinitis. Methods: This was intervention study using randomized control pre- and posttest design. Forty moderate-to-severe allergic rhinitis patients were randomly assigned into intervention group that received intracutaneous injection of 0,1 mL (2 x 105 CFUs) BCG (1173 P2 France) (n = 21) and control group that received 0,1 mL BCG solvent (n = 19), on the first day of treatment period. Total IgE level measurements were performed before treatment and on the last day of week 8 after vaccination. Clinical symptoms score and medications were also recorded everyday. Result: In the BCG group, total IgE level pre and post BCG vaccination were not significantly different (p=0.502). In the control group, total IgE level pre and post placebo were not significantly different too (p=0.528). In the BCG group, clinical symptoms score after BCG vaccination significantly decrease (p<0.05), so in the control group. Delta score pre and post treatment between the BCG and control group were not significantly different (p=0.257). No relationship between total IgE level and clinical symptoms score of allergic rhinitis (before treatment rs= -0.256, p=0,121; after treatment rs = -0.074; p= 0.657). Conclutions: BCG vaccination using 0,1 mL (2 x 105 CFUs)1173 P2 Paris does not decrease total IgE level and not improve clinical symptoms of allergic rhinitis. No relationship between total IgE level and clinical symptoms of allergic rhinitis. Key words: allergic rhinitis, BCG vaccination, total IgE level.

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:29348
Deposited By:Mr. Magister Biomedik Admin
Deposited On:14 Sep 2011 10:13
Last Modified:14 Sep 2011 10:13

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