JUMLAH MAKROFAG DAN INDEKS APOPTOSIS SEKITAR JARINGAN TUMOR PADA PENDERITA KEGANASAN PAYUDARA STADIUM III B YANG MENDAPAT INJEKSI VITAMIN C

Abstract

Background : Administration of vitamin C which has been reported to having effects as an immunostimulator and antitumour by increases macrophage number and apoptosis index. Breast cancer patients are likely to experience a decrease in immunity. Objective: To provide evidence of vitamin C as an immunostimulator for the cellular immunity through augmentation of macrophage number and apoptosis index surround the tumor tissue in breast cancer who received injection of vitamin C 2 after the third neoadjuvant chemotherapy. Methods: Randomized Clinical Trial with comparison group with pre and post test design. Treatment group was selected by simple randomization. Injection of vitamin C 2 gr/day for 5 days was administered to the treatment group after the third neoadjuvant chemotherapy. On the sixth day examine macrophage number and apoptosis index surround the tumor was conducted after mastectomy. Data analysis consists of descriptive analysis and hypotesis test. Result There was an increase of macrophage number in treatment group compared with control group with p= 0.000, There was an increase of apoptosis in treatment group compared with control group with p = 0.000 Conclusion: Vitamin C increases the macrophage number and apoptosis index surround the tumor in IIIB stage breast cancer patients after the third neoadjuvant chemotherapy. Keywords: Vitamin C, macrophage, apoptosis inde,x breast cancer, chemotherapy