KORELASI ANTARA KADAR SENG SERUM DENGAN BANGKITAN KEJANG DEMAM (CORRELATION BETWEEN SERUM ZINC LEVEL AND FEBRILE SEIZURE)

Abstract

Febrile seizures is the most common neurological disorder in children in which 2%-5% of children under 5 years old had experienced febrile seizures. Prognosis of febrile seizures is good, but worried the parents. There were only several studies that correlates serum zinc level and febrile seizure. Objective. Analyze the correlation between serum zinc level and febrile seizure. Method. A case control study was conducted in Dr.Kariadi hospital during April 2009 – March 2010 on 72 children aged 3 months – 5 years; 36 children with febrile seizures as case group and 36 children with febrile but without seizure as control group. Serum zinc level was measured by atomic absorption spectrophotometry at GAKI Laboratory, Medical Faculty Undip. Statistical analysis was done using Chi-square, Spearman correlation, and determinant analysis. Results. The mean serum zinc levels in case and control group were 111.73 g/mL and 114.56 g/mL, respectively (p=0.33). There was no correlation between serum zinc level and febrile seizure (r=0.114;p>0.05). Determinant analysis showed contribution of genetic factor (0.548), recurrence infection (0.493), risk of pregnancy and labor (0.364), temperature (0.309), developmental delayed (0.141), zinc serum level (-0.102), age (-0.041) with confusion matrix of 81.9% for prediction. Conclussion. The mean serum zinc level of febrile seizure is lower than febrile without fever but not significant. There is no correlation between serum zinc level and febrile seizure. Serum zinc level with genetic factor, recurrence infection, risk of pregnancy and labor, temperature, developmental delayed, and age may be used as a predictor of febrile seizure despite its low role. Keywords: febrile seizures, zinc serum.