Kumoro, A.C. and Hasan, M. (2006) Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent’s Hildebrand Solubility Parameter on Extraction Efficiency. In: 4th National Technical Postgraduate Symposium, Petaling Jaya, MALAYSIA.
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Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using standard soxhlet extraction method was investigated. The Hildebrand solubility parameter concept performed well when predicting lower polar solvent effect on extraction efficiency. However, ethanol extracted less andrographolide than methanol even though ethanol has closer Hildebrand solubility parameter value to andrographolide compared to that of methanol. Methanol’s shorter aliphatic chain and higher polarity, which lead to easier hydroxyl group liberation, seemed to contribute this discrepancy.
|Item Type:||Conference or Workshop Item (Paper)|
|Uncontrolled Keywords:||extraction, diterpenoid lactones, Andrographis paniculata, solvent, Hildeband solubility parameter.|
|Subjects:||T Technology > TP Chemical technology|
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Divisions:||Faculty of Engineering > Department of Chemical Engineering|
Faculty of Engineering > Department of Chemical Engineering
|Deposited By:||Dr. Andri Kumoro|
|Deposited On:||09 Jun 2009 14:29|
|Last Modified:||09 Jun 2009 14:29|
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