SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES USING METHANOL AS COSOLVENT

Abstract

The optimisation and design of any separation processes, such as the extraction of bio molecules from their natural resources require mathematical modelling. The objective of this work is to develop a mathematical model based on first order desorption rate of solute into supercritical solvent containing a mixture of supercritical carbon dioxide and methanol in the extraction of andrographolide from Andrographis paniculata leaves. Numerical calculations to obtain the adjustable parameter of the model using experimental data obtained from the supercritical carbon dioxide extraction (SCDE) of andrographolide at different methanol concentration and temperature were done using MATLAB software. The calculation results show that this model agrees well with the experimental data. Therefore, this model is capable for the optimisation and design of SCDE of andrographolide from Andrographis paniculata leaves with the presence of methanol as co – solvent.