SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES USING METHANOL AS COSOLVENT

Kumoro, A.C. and Hasan, M. (2006) SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES USING METHANOL AS COSOLVENT. In: International Conference on Modeling in Chemical and Biological Engineering Sciences, October 25-27 2006, Bangkok, THAILAND.

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Abstract

The optimisation and design of any separation processes, such as the extraction of bio molecules from their natural resources require mathematical modelling. The objective of this work is to develop a mathematical model based on first order desorption rate of solute into supercritical solvent containing a mixture of supercritical carbon dioxide and methanol in the extraction of andrographolide from Andrographis paniculata leaves. Numerical calculations to obtain the adjustable parameter of the model using experimental data obtained from the supercritical carbon dioxide extraction (SCDE) of andrographolide at different methanol concentration and temperature were done using MATLAB software. The calculation results show that this model agrees well with the experimental data. Therefore, this model is capable for the optimisation and design of SCDE of andrographolide from Andrographis paniculata leaves with the presence of methanol as co – solvent.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:modelling, extraction, supercritical carbon dioxide, co – solvent, andrographolide, Andrographis paniculata, MATLAB
Subjects:S Agriculture > S Agriculture (General)
T Technology > TP Chemical technology
Q Science > QK Botany
Q Science > QD Chemistry
S Agriculture > SD Forestry
R Medicine > RS Pharmacy and materia medica
Divisions:Faculty of Engineering > Department of Chemical Engineering
Faculty of Engineering > Department of Chemical Engineering
ID Code:266
Deposited By:Dr. Andri Kumoro
Deposited On:09 Jun 2009 12:40
Last Modified:09 Jun 2009 12:40

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