PERBEDAAN PENGARUH PEMBERIAN PROPOFOL DAN PENTHOTAL TERHADAP AGREGASI PLATELET THE DIFFERENCE EFFECTS OF PROPOFOL AND PENTHOTAL ADMINISTRATION ON THROMBOCYTE AGGREGATION

Abstract

ABSTRAK PERBEDAAN PENGARUH PEMBERIAN PROPOFOL DAN PENTHOTAL TERHADAP AGREGASI TROMBOSIT Arliansah*Widya Istanto**Noor Wijayahadi*** Latar belakang penelitian : Perdarahan perioperatif merupakan masalah yang sering dihadapi dalam setiap operasi. Penggunaan obat anestesi induksi mempunyai pengaruh menghambat agregasi trombosit. Propofol dan Penthotal mempengaruhi Agregasi Trombosit. Tujuan : Membuktikan perbedaan pengaruh Propofol dan Penthotal terhadap Agregasi Trombosit. Metode : Merupakan penelitian Randomized Clinical Control Trial pada 34 pasien yang menjalani anestesi umum, dibagi menjadi 2 kelompok (n=17), Propofol dan Penthotal. Masing-masing kelompok diperiksa TAT sebelum induksi dan 5 menit setelah induksi. Uji statistik pair t-test dan independent t-test terhadap propofol atau penthotal dan agregasi trombosit. Hasil : Agregasi maksimal trombosit, sebelum dan sesudah pemberian propofol atau penthotal berbeda bermakna. Kelompok penthotal persentase agregasi maksimal trombosit 68,73 ± 6,06% dan propofol 54,68 ± 9,55%, menunjukkan perbedaan yang bermakna antara keduanya (p=0,001). Hasil sesudah perlakuan, kelompok propofol 14 orang hipoagregasi (82,4%), dan 3 orang normoagregsi (17,6%). Sementara kelompok penthotal 5 orang hipoagregasi (29,4%), dan sisanya 12 orang normoagregasi (70,6%). Secara statistik propofol secara bermakna menyebabkan hipoagregasi daripada penthotal. Kesimpulan : Propofol secara bermakna menurunkan agregasi maksimal trombosit dan menyebabkan hipoagregasi lebih banyak daripada penthotal. Kata kunci : propofol, penthotal, ADP, agregasi trombosit. ABSTRACT THE DIFFERENCE EFFECTS OF PROPOFOL AND PENTHOTAL ADMINISTRATION ON PLATELET AGGREGATION Arliansah*Widya Istanto**Noor Wijayahadi*** Background : Perioperative bleeding is a serious and common problem in surgery. Some induction anesthetic agents are thought to inhibit platelet aggregation. The propofol and penthotal had effect on platelet aggregation. Objective : Determine the difference effects of propofol and penthotal administration on platelet aggregation. Method : An Randomized Clinical Control Trial study on 34 patients who received general anesthesia, divided into two groups (n: 17). Both groups received Propofol or Penthotal were examined TAT before and five minutes after induction All data were analyzed by pair t-test and independent t-test for Propofol or Penthotal and platelet aggregation. Result : Maximal platelet aggregation before and after the administration of propofol and penthotal is significant difference. In propofol and penthotal group, the percentage of maximal platelet aggregation was 54,93 ±9,38 and 66,26 ±8,94 (p=0,0001). We found 64,71% hypoaggregation, 17,65% mild hypo aggregation and 17,65% normo aggregation on propofol group, and 11,76% of hypo aggregation, 23,53% mild hypoaggregation and 64,71% normoaggregation on penthotal group. Statistically, propofol caused significant hypoaggregation of platelet compared to penthotal). Conclusion : Propofol significantly lowers the percentage of maximal platelet aggregation and causes more hypoaggregation than penthotal. Keywords : propofol, penthotal, ADP, platelet aggregation