PENGARUH PEMBERIAN ECHINACEA ORAL TERHADAP JUMLAH SEL T CD4 DAN UKURAN TUMOR PADA PENDERITA KARSINOMA MAMMA YANG MENDAPATKAN KEMOTERAPI THE EFFECTS OF ECHINACEA ON COUNT OF CD4 CELLS AND TUMOR SIZE AMONG BREAST CANCER PATIENT RECEIVING CHEMOTHERAPY REGIMENT

Hertanto, Didi (2009) PENGARUH PEMBERIAN ECHINACEA ORAL TERHADAP JUMLAH SEL T CD4 DAN UKURAN TUMOR PADA PENDERITA KARSINOMA MAMMA YANG MENDAPATKAN KEMOTERAPI THE EFFECTS OF ECHINACEA ON COUNT OF CD4 CELLS AND TUMOR SIZE AMONG BREAST CANCER PATIENT RECEIVING CHEMOTHERAPY REGIMENT. Masters thesis, UNIVERSITAS DIPONEGORO.

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Abstract

ABSTRAK Latar belakang : Echinacea Sp adalah tanaman yang dipercaya meningkatkan aktivitas sistem imun seluler. Penderita dengan kanker payudara yang mendapatkan kemoterapi akan mengalami penurunan sistem imun. Salah satu respon imunitas seluler pada kanker adalah CD4 dan responnya terhadap ukuran tumor. Tujuan : Membuktikan adanya perbedaan jumlah sel CD4 dan ukuran tumor pada penderita karsinoma mama yang mendapatkan kemoterapi dan Echinacea oral. Dan adakah hubungan antara perubahan jumlah sel CD4 dengan ukuran tumor. Metoda : Double blind control trial pada penderita karsinoma ductus invasiv stadium IIIb. 15 penderita sebagai kelompok kontrol: yang menjalani kemoterapi dan placebo , dan 15 penderita sebagai kelompok perlakuan: yang menjalani kemoterapi dan pemberian echinacea. Sebelum perlakuan diukur jumlah sel CD4 dan ukuran tumor. Setelah 28 hari dilakukan pengukuran ulang keduanya. Analisis statistik menggunakan uji t 2 kelompok independen dan korelasi pearson. Hasil : Terdapat perbedaan bermakna (p=0,03) pada jumlah sel CD4 antara kelompok kontrol (430,13+136,82) dan kelompok perlakuan ( 623,93+297,57). Terdapat perbedaan bermakna (p=0,001) pada ukuran tumor antara kelompok kontrol (5,19+0,87) dan kelompok perlakuan(4,1+0,62).Tidak didapat perbedaan bermakna ( p=0,24) pada perubahan jumlah sel CD4 antara kelompok kontrol (-19,83+26,7)dan kelompok perlakuan.(-6,52+34,28).Terdapat perbedaan bermakna (p=0,01) pada perubahan ukuran tumor antara kelompok kontrol(-17,99+3,52) dan kelompok perlakuan(-22,51+5,5). Didapatkan korelasi negatif sedang (-0,430) yang bermakna (p=0,018) antara perubahan jumlah sel CD4 dengan ukuran tumor. Simpulan : Terdapat perbedaan jumlah sel CD4, ukuran tumor dan korelasi negatif pada pemberian echinaceae oral pada penderita karsinoma mamma yang mendapatkan kemoterapi. Kata kunci : Echinacea sp, jumlah sel CD4, ukuran tumor, ca ductus invasif, kemoterapi. ABSTRACT Background : Echinacea Sp is effective in activity immune system, cellular system in particular. The acceleration of immune system is very much needed for this cancer patient one of the cellular immune respon useful for cancer patient is the CD4 count and its respons to the size of the tumor. Objective : To get evidences that there is difference in CD4 count and tumor size between karsinoma mama patients who are given oral Echinacea. This study is also intended to access that there is a relation between the change of count of CD4 with the change the size of the tumor. Method : a double blind control trial to karsinoma ductus invasive stadium IIIb, fifteen of them, as the control group were treated with chemotheraphy and placebo and fifteen patients as the experiment group were treated with chemotherapi and Echinacea. Prior to the treatments the levels of CD4 count and tumor size were measured. After treatments (28 days) the measuring were repeated . Statistic analysis was conducted using t test of two independent groups and pearson correlation analysis. Out come :There is a significant (p=0,03) in count of CD4 between experiment group (623,9+297,5) and control group (430,1+136,8).There is also significant (p=0.001) in tumor size between the experiment group(4,1+0.6) and control group (5,1+0,87) . There is no significant difference (p=0.24) in the change of count CD4 between the experiment group(-6,5+34,2) and control grup(-19,8+26,7) . There is significant difference (p=0,01) between the experiment group(-22,5+5,5) and control group(- 17,99+3,5). The pearson analysis showed negative (-0.430) in the significance level (p=0.018) between the change of CD4 count and the change of tumor size. Conclusion : there is difference of CD4 count, tumor size and negative correlation in the treatment of oral Echinacea for carsinoma mama patient who are having chemotherapi treatment. Key word : Echinacea sp, CD4 cells count, Tumor size

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:24698
Deposited By:Mr UPT Perpus 2
Deposited On:15 Dec 2010 10:14
Last Modified:15 Dec 2010 10:14

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